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E1-E2_ATPase PF00122.15 E1-E2 ATPase

E1-N PF14463.1 E1 N-terminal domain

E1_DerP2_DerF2 PF02221.10 ML domain

E1_dh PF00676.15 Dehydrogenase E1 component

E2 PF08199.6 Bacteriophage E2-like protein

E2F_TDP PF02319.15 E2F/DP family winged-helix DNA-binding domain

E2R135 PF11570.3 Coiled-coil receptor-binding R-domain of colicin E2

E2_bind PF08825.5 E2 binding domain

E3_binding PF02817.12 e3 binding domain

E3_UbLigase_EDD PF11547.3 E3 ubiquitin ligase EDD

E3_UbLigase_R4 PF13764.1 E3 ubiquitin-protein ligase UBR4

E6 PF00518.12 Early Protein (E6)

E7 PF00527.13 E7 protein, Early protein

EABR PF12180.3 TSG101 and ALIX binding domain of CEP55

Ead_Ea22 PF13935.1 Ead/Ea22-like protein

EAF PF09816.4 RNA polymerase II transcription elongation factor

Eaf7 PF07904.8 Chromatin modification-related protein EAF7

EAL PF00563.15 EAL domain

EamA PF00892.15 EamA-like transporter family

EAP30 PF04157.11 EAP30/Vps36 family

Eapp_C PF10238.4 E2F-associated phosphoprotein

EAV_GS PF01309.13 Equine arteritis virus small envelope glycoprotein

EB PF01683.13 EB module

EB1 PF03271.12 EB1-like C-terminal motif

EB1_binding PF05937.6 EB-1 Binding Domain

EBA-175_VI PF11556.3 Erythrocyte binding antigen 175

Ebola_NP PF05505.7 Ebola nucleoprotein

EBP PF05241.7 Emopamil binding protein

Ebp2 PF05890.7 Eukaryotic rRNA processing protein EBP2

EBP50_C-term PF09007.6 EBP50, C-terminal

EBV-NA1 PF02905.9 Epstein Barr virus nuclear antigen-1, DNA-binding domain

EBV-NA3 PF05009.7 Epstein-Barr virus nuclear antigen 3 (EBNA-3)

EB_dh PF09459.5 Ethylbenzene dehydrogenase

ECF-ribofla_trS PF07155.7 ECF-type riboflavin transporter, S component

ECH PF00378.15 Enoyl-CoA hydratase/isomerase family

ECH_C PF13766.1 2-enoyl-CoA Hydratase C-terminal region

ECIST_Cterm PF14784.1 C-terminal domain of the ECSIT protein

EcKinase PF02958.15 Ecdysteroid kinase

Ecl1 PF12855.2 Life-span regulatory factor

Eclosion PF04736.7 Eclosion hormone

ECM1 PF05782.6 Extracellular matrix protein 1 (ECM1)

ECM11 PF15463.1 Extracellular mutant protein 11

Ecm29 PF13001.2 Proteasome stabiliser

Ecm33 PF12454.3 GPI-anchored cell wall organization protein

Eco57I PF07669.6 Eco57I restriction-modification methylase

EcoEI_R_C PF08463.5 EcoEI R protein C-terminal

EcoR124_C PF12008.3 Type I restriction and modification enzyme - subunit R C terminal

EcoRI PF02963.11 Restriction endonuclease EcoRI

EcoRII-C PF09019.6 EcoRII C terminal

EcoRII-N PF09217.5 Restriction endonuclease EcoRII, N-terminal

EcoRI_methylase PF13651.1 Adenine-specific methyltransferase EcoRI

Ecotin PF03974.8 Ecotin

ECR1_N PF14382.1 Exosome complex exonuclease RRP4 N-terminal region

EcsB PF05975.7 Bacterial ABC transporter protein EcsB

EcsC PF12787.2 EcsC protein family

ECSIT PF06239.6 Evolutionarily conserved signalling intermediate in Toll pathway

Ectatomin PF06457.6 Ectatomin

Ectoine_synth PF06339.7 Ectoine synthase

EDR1 PF14381.1 Ethylene-responsive protein kinase Le-CTR1

EF-1_beta_acid PF10587.4 Eukaryotic elongation factor 1 beta central acidic region

EF-hand_1 PF00036.27 EF hand

EF-hand_10 PF14788.1 EF hand

EF-hand_2 PF09068.6 EF hand

EF-hand_3 PF09069.6 EF-hand

EF-hand_4 PF12763.2 Cytoskeletal-regulatory complex EF hand

EF-hand_5 PF13202.1 EF hand

EF-hand_6 PF13405.1 EF-hand domain

EF-hand_7 PF13499.1 EF-hand domain pair

EF-hand_8 PF13833.1 EF-hand domain pair

EF-hand_9 PF14658.1 EF-hand domain

EF-hand_like PF09279.6 Phosphoinositide-specific phospholipase C, efhand-like

EF1G PF00647.14 Elongation factor 1 gamma, conserved domain

EF1_GNE PF00736.14 EF-1 guanine nucleotide exchange domain

EFF-AFF PF14884.1 Type I membrane glycoproteins cell-cell fusogen

Effector_1 PF04518.7 Effector from type III secretion system

EFG_C PF00679.19 Elongation factor G C-terminus

EFG_II PF14492.1 Elongation Factor G, domain II

EFG_IV PF03764.13 Elongation factor G, domain IV

EFhand_Ca_insen PF08726.5 Ca2+ insensitive EF hand

EFP PF01132.15 Elongation factor P (EF-P) OB domain

EFP_N PF08207.7 Elongation factor P (EF-P) KOW-like domain

EF_assoc_1 PF08355.7 EF hand associated

EF_assoc_2 PF08356.7 EF hand associated

EF_TS PF00889.14 Elongation factor TS

EGF PF00008.22 EGF-like domain

EGF_2 PF07974.8 EGF-like domain

EGF_3 PF12947.2 EGF domain

EGF_alliinase PF04863.8 Alliinase EGF-like domain

EGF_CA PF07645.10 Calcium-binding EGF domain

EGF_MSP1_1 PF12946.2 MSP1 EGF domain 1

Egg_lysin PF01303.12 Egg lysin (Sperm-lysin)

EGL-1 PF11430.3 Programmed cell death activator EGL-1

Ehbp PF10622.4 Energy-converting hydrogenase B subunit P (EhbP)

EHN PF06441.7 Epoxide hydrolase N terminus

Ehrlichia_rpt PF09528.5 Ehrlichia tandem repeat (Ehrlichia_rpt)

EH_Signature PF15611.1 EH_Signature domain

EI24 PF07264.6 Etoposide-induced protein 2.4 (EI24)

EIAV_GP90 PF00971.13 EIAV coat protein, gp90

EIAV_Rev PF11129.3 Rev protein of equine infectious anaemia virus

EIF4E-T PF10477.4 Nucleocytoplasmic shuttling protein for mRNA cap-binding EIF4E

EIF_2_alpha PF07541.7 Eukaryotic translation initiation factor 2 alpha subunit

EII-GUT PF03608.8 PTS system enzyme II sorbitol-specific factor

EII-Sor PF03609.9 PTS system sorbose-specific iic component

EIIA-man PF03610.11 PTS system fructose IIA component

EIIBC-GUT_C PF07663.6 Sorbitol phosphotransferase enzyme II C-terminus

EIIBC-GUT_N PF03612.9 Sorbitol phosphotransferase enzyme II N-terminus

EIIC-GAT PF03611.9 PTS system sugar-specific permease component

EIID-AGA PF03613.9 PTS system mannose/fructose/sorbose family IID component

EIN3 PF04873.8 Ethylene insensitive 3

EKR PF10371.4 Domain of unknown function

ELF PF03317.8 ELF protein

Elf-1_N PF12310.3 Transcription factor protein N terminal

Elf1 PF05129.8 Transcription elongation factor Elf1 like

ELFV_dehydrog PF00208.16 Glutamate/Leucine/Phenylalanine/Valine dehydrogenase

ELFV_dehydrog_N PF02812.13 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain

ELH PF02323.10 Egg-laying hormone precursor

Elicitin PF00964.12 Elicitin

ELK PF03789.8 ELK domain

ELL PF10390.4 RNA polymerase II elongation factor ELL

ELM2 PF01448.19 ELM2 domain

ELMO_CED12 PF04727.8 ELMO/CED-12 family

ELO PF01151.13 GNS1/SUR4 family

Elong-fact-P_C PF09285.6 Elongation factor P, C-terminal

Elongin_A PF06881.6 RNA polymerase II transcription factor SIII (Elongin) subunit A

Elong_Iki1 PF10483.4 Elongator subunit Iki1

ELYS PF13934.1 Nuclear pore complex assembly

EMA PF02488.10 Merozoite Antigen

EMG1 PF03587.9 EMG1/NEP1 methyltransferase

EMI PF07546.8 EMI domain

EMP24_GP25L PF01105.19 emp24/gp25L/p24 family/GOLD

EMP70 PF02990.11 Endomembrane protein 70

EmrE PF13536.1 Multidrug resistance efflux transporter

Enamelin PF15362.1 Enamelin

End3 PF12761.2 Actin cytoskeleton-regulatory complex protein END3

EndIII_4Fe-2S PF10576.4 Iron-sulfur binding domain of endonuclease III

Endomucin PF07010.7 Endomucin

Endonuc-BglII PF09195.6 Restriction endonuclease BglII

Endonuc-BsobI PF09194.5 Restriction endonuclease BsobI

Endonuc-dimeris PF09124.5 T4 recombination endonuclease VII, dimerisation

Endonuc-EcoRV PF09233.6 Restriction endonuclease EcoRV

Endonuc-FokI_C PF09254.6 Restriction endonuclease FokI, C terminal

Endonuc-HincII PF09226.6 Restriction endonuclease HincII

Endonuc-MspI PF09208.5 Restriction endonuclease MspI

Endonuc-PvuII PF09225.5 Restriction endonuclease PvuII

Endonuclease_1 PF04231.8 Endonuclease I

Endonuclease_5 PF04493.9 Endonuclease V

Endonuclease_7 PF02945.10 Recombination endonuclease VII

Endonuclease_NS PF01223.18 DNA/RNA non-specific endonuclease

Endonuclea_NS_2 PF13930.1 DNA/RNA non-specific endonuclease

Endonuc_BglI PF14562.1 Restriction endonuclease BglI

Endonuc_Holl PF10107.4 Endonuclease related to archaeal Holliday junction resolvase

Endonuc_subdom PF09062.5 PI-PfuI Endonuclease subdomain

Endostatin PF06482.6 Collagenase NC10 and Endostatin

Endosulfine PF04667.12 cAMP-regulated phosphoprotein/endosulfine conserved region

Endothelin PF00322.12 Endothelin family

Endotoxin_C PF03944.9 delta endotoxin

Endotoxin_M PF00555.14 delta endotoxin

Endotoxin_mid PF09131.5 Bacillus thuringiensis delta-Endotoxin, middle domain

Endotoxin_N PF03945.9 delta endotoxin, N-terminal domain

EndoU_bacteria PF14436.1 Bacterial EndoU nuclease

End_beta_barrel PF12195.3 Beta barrel domain of bacteriophage endosialidase

End_beta_propel PF12217.3 Catalytic beta propeller domain of bacteriophage endosialidase

End_N_terminal PF12218.3 N terminal extension of bacteriophage endosialidase

End_tail_spike PF12219.3 Catalytic domain of bacteriophage endosialidase

Engrail_1_C_sig PF10525.4 Engrailed homeobox C-terminal signature domain

Enhancin PF03272.8 Viral enhancin protein

Enkurin PF13864.1 Calmodulin-binding

Eno-Rase_FAD_bd PF07055.7 Enoyl reductase FAD binding domain

Eno-Rase_NADH_b PF12242.3 NAD(P)H binding domain of trans-2-enoyl-CoA reductase

ENOD40 PF08247.6 ENOD40 protein

ENOD93 PF03386.9 Early nodulin 93 ENOD93 protein

Enolase_C PF00113.17 Enolase, C-terminal TIM barrel domain

Enolase_N PF03952.11 Enolase, N-terminal domain

Enoyl_reductase PF12241.3 Trans-2-enoyl-CoA reductase catalytic region

ENT PF03735.9 ENT domain

EntA_Immun PF08951.5 Enterocin A Immunity

Entericidin PF08085.6 Entericidin EcnA/B family

Enterotoxin_a PF01375.12 Heat-labile enterotoxin alpha chain

Enterotoxin_b PF01376.13 Heat-labile enterotoxin beta chain

Enterotoxin_HS1 PF08090.6 Heat stable E.coli enterotoxin 1

Enterotoxin_ST PF02048.11 Heat-stable enterotoxin ST

ENTH PF01417.15 ENTH domain

Env-gp36 PF09590.5 Lentivirus surface glycoprotein

EnY2 PF10163.4 Transcription factor e(y)2

EOS1 PF12326.3 N-glycosylation protein

Ependymin PF00811.13 Ependymin

EphA2_TM PF14575.1 Ephrin type-A receptor 2 transmembrane domain

Ephrin PF00812.12 Ephrin

Ephrin_lbd PF01404.14 Ephrin receptor ligand binding domain

Epiglycanin_C PF14654.1 Mucin, catalytic, TM and cytoplasmic tail region

Epiglycanin_TR PF05647.6 Tandem-repeating region of mucin, epiglycanin-like

Epimerase PF01370.16 NAD dependent epimerase/dehydratase family

Epimerase_2 PF02350.14 UDP-N-acetylglucosamine 2-epimerase

Epimerase_Csub PF13950.1 UDP-glucose 4-epimerase C-term subunit

EPL1 PF10513.4 Enhancer of polycomb-like

EpoR_lig-bind PF09067.5 Erythropoietin receptor, ligand binding

EPO_TPO PF00758.13 Erythropoietin/thrombopoietin

EppA_BapA PF07268.6 Exported protein precursor (EppA/BapA)

EpsG PF14897.1 EpsG family

Epsilon_antitox PF08998.6 Bacterial epsilon antitoxin

EPSP_synthase PF00275.15 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase)

EPTP PF03736.12 EPTP domain

EpuA PF11772.3 DNA-directed RNA polymerase subunit beta

EPV_E5 PF08135.6 Major transforming protein E5 family

Equine_IAV_S2 PF06502.6 Equine infectious anaemia virus S2 protein

ER PF01133.12 Enhancer of rudimentary

ER-remodelling PF14755.1 Intracellular membrane remodeller

ERAP1_C PF11838.3 ERAP1-like C-terminal domain

ERbeta_N PF12497.3 Estrogen receptor beta

ERCC4 PF02732.10 ERCC4 domain

ERF PF04404.7 ERF superfamily

Erf4 PF10256.4 Golgin subfamily A member 7/ERF4 family

Erg28 PF03694.8 Erg28 like protein

ERG2_Sigma1R PF04622.7 ERG2 and Sigma1 receptor like protein

ERG4_ERG24 PF01222.12 Ergosterol biosynthesis ERG4/ERG24 family

ERGIC_N PF13850.1 Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC)

ERK-JNK_inhib PF15002.1 ERK and JNK pathways, inhibitor

ERM PF00769.14 Ezrin/radixin/moesin family

ErmC PF06308.6 23S rRNA methylase leader peptide (ErmC)

ERO1 PF04137.10 Endoplasmic Reticulum Oxidoreductin 1 (ERO1)

ERp29 PF07749.7 Endoplasmic reticulum protein ERp29, C-terminal domain

ERp29_N PF07912.8 ERp29, N-terminal domain

Erp_C PF06780.6 Erp protein C-terminus

Erv26 PF04148.8 Transmembrane adaptor Erv26

Erythro-docking PF09277.6 Erythronolide synthase, docking

Erythrovirus_X PF06795.6 Erythrovirus X protein

Erythro_esteras PF05139.9 Erythromycin esterase

Ery_res_leader1 PF08051.6 Erythromycin resistance leader peptide

Ery_res_leader2 PF08057.6 Erythromycin resistance leader peptide

ER_lumen_recept PF00810.13 ER lumen protein retaining receptor

Es2 PF09751.4 Nuclear protein Es2

ESAG1 PF03238.8 ESAG protein

ESCRT-II PF05871.7 ESCRT-II complex subunit

EspA PF03433.8 EspA-like secreted protein

EspB PF05802.6 Enterobacterial EspB protein

EspF PF04806.7 EspF protein repeat

EspG PF06872.6 EspG protein

ESPR PF13018.1 Extended Signal Peptide of Type V secretion system

ESR1_C PF12743.2 Oestrogen-type nuclear receptor final C-terminal

EssA PF10661.4 WXG100 protein secretion system (Wss), protein EssA

ESSS PF10183.4 ESSS subunit of NADH:ubiquinone oxidoreductase (complex I)

EST1 PF10374.4 Telomerase activating protein Est1

EST1_DNA_bind PF10373.4 Est1 DNA/RNA binding domain

Esterase PF00756.15 Putative esterase

Esterase_phd PF10503.4 Esterase PHB depolymerase

ESX-1_EspG PF14011.1 EspG family

ET PF01684.11 ET module

ETAA1 PF15350.1 Ewing's tumour-associated antigen 1 homologue

ETC_C1_NDUFA4 PF04800.7 ETC complex I subunit conserved region

ETC_C1_NDUFA5 PF04716.9 ETC complex I subunit conserved region

ETF PF01012.16 Electron transfer flavoprotein domain

ETF_alpha PF00766.14 Electron transfer flavoprotein FAD-binding domain

ETF_QO PF05187.8 Electron transfer flavoprotein-ubiquinone oxidoreductase

EthD PF07110.6 EthD domain

Etmic-2 PF06670.6 Microneme protein Etmic-2

ETRAMP PF09716.5 Malarial early transcribed membrane protein (ETRAMP)

Ets PF00178.17 Ets-domain

ETS_PEA3_N PF04621.8 PEA3 subfamily ETS-domain transcription factor N terminal domain

ETX_MTX2 PF03318.8 Clostridium epsilon toxin ETX/Bacillus mosquitocidal toxin MTX2

Euplotes_phero PF05842.6 Euplotes octocarinatus mating pheromone protein

EURL PF06937.6 EURL protein

EutA PF06277.6 Ethanolamine utilisation protein EutA

EutB PF06751.6 Ethanolamine ammonia lyase large subunit (EutB)

EutC PF05985.6 Ethanolamine ammonia-lyase light chain (EutC)

EutH PF04346.7 Ethanolamine utilisation protein, EutH

EutN_CcmL PF03319.8 Ethanolamine utilisation protein EutN/carboxysome

EutQ PF06249.7 Ethanolamine utilisation protein EutQ

EVC2_like PF12297.3 Ellis van Creveld protein 2 like protein

EVE PF01878.13 EVE domain

EVI2A PF05399.6 Ectropic viral integration site 2A protein (EVI2A)

Evr1_Alr PF04777.8 Erv1 / Alr family

ExbD PF02472.11 Biopolymer transport protein ExbD/TolR

Exc PF07825.6 Excisionase-like protein

Excalibur PF05901.6 Excalibur calcium-binding domain

Exo5 PF09810.4 Exonuclease V - a 5' deoxyribonuclease

Exo70 PF03081.10 Exo70 exocyst complex subunit

ExoD PF06055.7 Exopolysaccharide synthesis, ExoD

Exonuc_VIII PF06630.6 Enterobacterial exodeoxyribonuclease VIII

Exonuc_VII_L PF02601.10 Exonuclease VII, large subunit

Exonuc_VII_S PF02609.11 Exonuclease VII small subunit

Exonuc_V_gamma PF04257.9 Exodeoxyribonuclease V, gamma subunit

Exonuc_X-T_C PF08411.5 Exonuclease C-terminal

EXOSC1 PF10447.4 Exosome component EXOSC1/CSL4

Exosortase_EpsH PF09721.5 Transmembrane exosortase (Exosortase_EpsH)

Exostosin PF03016.10 Exostosin family

Exotox-A_bind PF09101.5 Exotoxin A binding

Exotox-A_cataly PF09009.5 Exotoxin A catalytic

Exotox-A_target PF09102.5 Exotoxin A, targeting

Exo_endo_phos PF03372.18 Endonuclease/Exonuclease/phosphatase family

Exo_endo_phos_2 PF14529.1 Endonuclease-reverse transcriptase

EXS PF03124.9 EXS family

Extensin-like_C PF06904.7 Extensin-like protein C-terminus

Extensin_1 PF02095.10 Extensin-like protein repeat

Extensin_2 PF04554.8 Extensin-like region

EZH2_WD-Binding PF11616.3 WD repeat binding protein EZH2

EzrA PF06160.7 Septation ring formation regulator, EzrA

E_Pc_C PF06752.7 Enhancer of Polycomb C-terminus

E_raikovi_mat PF06360.6 Euplotes raikovi mating pheromone

ecTbetaR2 PF08917.5 Transforming growth factor beta receptor 2 ectodomain

efb-c PF12199.3 Extracellular fibrinogen binding protein C terminal

efThoc1 PF11957.3 THO complex subunit 1 transcription elongation factor

eIF-1a PF01176.14 Translation initiation factor 1A / IF-1

eIF-3c_N PF05470.7 Eukaryotic translation initiation factor 3 subunit 8 N-terminus

eIF-3_zeta PF05091.7 Eukaryotic translation initiation factor 3 subunit 7 (eIF-3)

eIF-4B PF06273.6 Plant specific eukaryotic initiation factor 4B

eIF-5a PF01287.15 Eukaryotic elongation factor 5A hypusine, DNA-binding OB fold

eIF-5_eIF-2B PF01873.12 Domain found in IF2B/IF5

eIF-6 PF01912.13 eIF-6 family

eIF2A PF08662.6 Eukaryotic translation initiation factor eIF2A

eIF2_C PF09173.6 Initiation factor eIF2 gamma, C terminal

eIF3g PF12353.3 Eukaryotic translation initiation factor 3 subunit G

eIF3_N PF09440.5 eIF3 subunit 6 N terminal domain

eIF3_p135 PF12807.2 Translation initiation factor eIF3 subunit 135

eIF3_subunit PF08597.5 Translation initiation factor eIF3 subunit

eIF_4EBP PF05456.6 Eukaryotic translation initiation factor 4E binding protein (EIF4EBP)

eIF_4G1 PF12152.3 Eukaryotic translation initiation factor 4G1

eRF1_1 PF03463.10 eRF1 domain 1

eRF1_2 PF03464.10 eRF1 domain 2

eRF1_3 PF03465.10 eRF1 domain 3