The sequences which have been used as reference for the generation of profiles for the family MM_CoA_mutase are highlighted in red. The profiles and the reference sequences for this family are given in a tar zipped format (Profiles are in ASN.1 format).

Download the tar zipped file.
Click here for help on generation of RPS-BLAST databases from the files given in above link

MUTA_CAEEL/50-567                   WNTPEGIPIKPLYL-RSDRDCDAQ--RSVELPGQFPFTRGPYPTMYTQRPWTIRQYAGFST
MUTA_HUMAN/61-576                   WHTPEGISIKPLYS--KRDTMDLPE----ELPGVKPFTRGPYPTMYTFRPWTIRQYAGFST
MUTA_MYCTU/24-525                   GVLSKSNRTDSAQL--GDHPERLLDTQTADGFAIRALYTAFDELPEPPLPGQWPFVRGGDP
MUTA_PORGI/39-528                   WRTNEGFNVNPFYR--REDIEDLKT--TTSLPDEYPYVRSTRMHNE----WLVRQ----DI
MUTA_STRCM/29-530                   GVVRKSGKDVS-----GTAAEEALSTTLEDGLTTRPLYTARDAAPDAGFPGFAPFVRGSVP
MUTB_MYCTU/50-578                   WHTPEGIDVTPVYIAADRAAAEAEGYPLHSFPGEPPFVRGPYPTMYVNQPWTIRQYAGFST
MUTB_PORGI/33-549                   WRTPEQIMVKPLYT--KDDLEGME--HLDYVSGLPPFLRGPYSGMYPMRPWTIRQYAGFST
MUTB_PROFR/38-559                   WETAEQIPVGTLFN--EDVYKDMDW--LDTYAGIPPFVHGPYATMYAFRPWTIRQYAGFST
O28068_ARCFU/25-542                 FKTSSGIVVDRLYT-PEDVEIDYEN--KLGYPGVYPFTRGVYPTMYRGRLWTMRQYAGFGT
O66005_STRCM/27-560                 FTTLSGDPVDPVYGPRPGDTYDGFE--RIGWPGEYPFTRGLYATGYRGRTWTIRQFAGFGN
SCPA_ECOLI/27-542                   HQTAEGIAIKPLYT--EADLDNLEV--TGTLPGLPPYVRGPRATMYTAQPWTIRQYAGFST


MUTA_CAEEL/50-567                   VEESNKFYKENIKAGQQGLSVAFDLATHRGYDSDNPRVFGDVGMAGVAVDSVEDMRQLFDG
MUTA_HUMAN/61-576                   VEESNKFYKDNIKAGQQGLSVAFDLATHRGYDSDNPRVRGDVGMAGVAIDTVEDTKILFDG
MUTA_MYCTU/24-525                   LRDVHSGWKVAEAFPANGATADTNAAVLAALGEGVSALLIRVGESGVAPD---RLTALLSG
MUTA_PORGI/39-528                   VVGDN----VAEAN-----EKALDL-----LNKGVDSLGFYLKKVHINVD---TLAALLKD
MUTA_STRCM/29-530                   EGNTPGGWDVRQRY-ASADPARTNEAVLTDLENGVTSLWLTLGSAGLPVT---GLERALDG
MUTB_MYCTU/50-578                   AADSNAFYRRNLAAGQKGLSVAFDLATHRGYDSDHPRVQGDVGMAGVAIDSILDMRQLFDG
MUTB_PORGI/33-549                   AEESNAFYRRNLASGQKGLSVAFDLATHRGYDADHSRVVGDVGKAGVSICSLEDMKVLFDG
MUTB_PROFR/38-559                   AKESNAFYRRNLAAGQKGLSVAFDLPTHRGYDSDNPRVAGDVGMAGVAIDSIYDMRELFAG
O28068_ARCFU/25-542                 AEETNRRYRYLLEQGQTGLSVAFDLPTQIGYDSDHPMALGEVGKVGVAIDTIEDMEILFNG
O66005_STRCM/27-560                 AEQTNERYKMILANGGGGLSVAFDMPTLMGRDSDDPRSLGEVGHCGVAIDSAADMEVLFKD
SCPA_ECOLI/27-542                   AKESNAFYRRNLAAGQKGLSVAFDLATHRGYDSDNPRVAGDVGKAGVAIDTVEDMKVLFDQ


MUTA_CAEEL/50-567                   INLEKMS----VSMTMNGAVVPVLAMYVVAAEEAGVSRKLLAGTIQNDILKEFMVRNTYIY
MUTA_HUMAN/61-576                   IPLEKMS----VSMTMNGAVIPVLANFIVTGEEQGVPKEKLTGTIQNDILKEFMVRNTYIF
MUTA_MYCTU/24-525                   VYLNLAP----VILDAGADYRPACDVMLALVAQLDP---GQRDTLSIDLGADPLTASLRDR
MUTA_PORGI/39-528                   IELTAVELNFNCCITRAADLLSAFSAYVK---KVGADPNKCHGSVSYDPFKKQLVRGV---
MUTA_STRCM/29-530                   VYLDLVP----VALDAGSEAATAARELLRLYEAAG----VADDAVRGTLGADPLGHEARTG
MUTB_MYCTU/50-578                   IDLSTVS----VSMTMNGAVLPILALYVVAAEEQGVAPEQLAGTIQNDILKEFMVRNTYIY
MUTB_PORGI/33-549                   IPLSKMS----VSMTMNGAVLPILAFYINAGLEQGAKLEEMAGTIQNDILKEFMVRNTYIY
MUTB_PROFR/38-559                   IPLDQMS----VSMTMNGAVLPILALYVVTAEEQGVKPEQLAGTIQNDILKEFMVRNTYIY
O28068_ARCFU/25-542                 IPLGKVS----TSMTINSTCAQILSMYVAVAEKQGVERANLRGTVQNDMLKEYIARGTYIF
O66005_STRCM/27-560                 IPLGDVT----TSMTISGPAVPVFCMYLVAAERQGVDPAVLNGTLQTDIFKEYIAQKEWLF
SCPA_ECOLI/27-542                   IPLDKMS----VSMTMNGAVLPVLAFYIVAAEEQGVTPDKLTGTIQNDILKEYLCRNTYIY


MUTA_CAEEL/50-567                   PPEPSMRIIGDIFAYTSREMPKFNSISISGYHMQEAGADAVLEMAFTIADGIQYCETGLNA
MUTA_HUMAN/61-576                   PPEPSMKIIADIFEYTAKHMPKFNSISISGYHMQEAGADAILELAYTLADGLEYSRTGLQA
MUTA_MYCTU/24-525                   PAPPIEEVVAVASRAAGER--GLRAITVDGPAFHNLGATAATELAATVAAAVAYLRVLTES
MUTA_PORGI/39-528                   -SNPDWVKMTLPVMDAARELPAFRVLNVNAVNLSDAGAFITQELGYALAWGAELLDKLTDA
MUTA_STRCM/29-530                   EKSTSFAAVAELARLCGERYPGLRALTVDALPYHEAGASAAQELGASLATGVEYLRALHDK
MUTB_MYCTU/50-578                   PPKPSMRIISDIFAYTSAKMPKFNSISISGYHIQEAGATADLELAYTLADGVDYIRAGLNA
MUTB_PORGI/33-549                   PPEFSMRIIADIFEYTSQNMPKFNSISISGYHMQEAGATADIEMAYTLADGMQYLKAGIDA
MUTB_PROFR/38-559                   PPQPSMRIISEIFAYTSANMPKWNSISISGYHMQEAGATADIEMAYTLADGVDYIRAGESV
O28068_ARCFU/25-542                 PPEPSLRLATDIIMFCAKEMPKWNSISISGYHMEEAGATPVQEVAFTLADGITYVEKVIER
O66005_STRCM/27-560                 QPEPHLRLIGDLMEHCARDIPAYKPLSVSGYHIREAGATAAQELAYTLADGFGYVELGLSR
SCPA_ECOLI/27-542                   PPKPSMRIIADIIAWCSGNMPRFNTISISGYHMGEAGANCVQQVAFTLADGIEYIKAAISA


MUTA_CAEEL/50-567                   GLTIDAFAPRLSFFWGISMNFYMEIAKMRAARRLWANLIKERFS--PKSDKSMMLRTHSQT
MUTA_HUMAN/61-576                   GLTIDEFAPRLSFFWGIGMNFYMEIAKMRAGRRLWAHLIEKMFQ--PKNSKSLLLRAHCQT
MUTA_MYCTU/24-525                   GLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEV-----VGDPGGGAAVVHAET
MUTA_PORGI/39-528                   GYKPEEIASRIKFNFGIGSNYFMEIAKFRAARWLWAQIVGS-YGDQYKNETAK-IHQHATT
MUTA_STRCM/29-530                   GLGVEKAFAQLEFRFAATADQFLTIAKLRAARRLWARVAEV-----SGVPAAGAQRQHAVT
MUTB_MYCTU/50-578                   GLDIDSFAPRLSFFWGIGMNFFMEVAKLRAGRLLWSELVAQ-FA--PKSAKSLSLRTHSQT
MUTB_PORGI/33-549                   GIDVDAFAPRLSFFWAIGVNHFMEIAKMRAARLLWAKIVKS-FG--AKNPKSLALRTHSQT
MUTB_PROFR/38-559                   GLNVDQFAPRLSFFWGIGMNFFMEVAKLRAARMLWAKLVHQ-FG--PKNPKSMSLRTHSQT
O28068_ARCFU/25-542                 GMDVDSFAPRLSFFFAAGNNFLEEIAKFRAARRLWARIMKERFN--AKNPRSMMLRFHVQT
O66005_STRCM/27-560                 GLDVDVFAPGLSFFFDAHVDFFEEIAKFRAARRIWARWLRDEYG--AKTEKAQWLRFHTQT
SCPA_ECOLI/27-542                   GLKIDDFAPRLSFFFGIGMDLFMNVAMLRAARYLWSEAVSG-FG--AQDPKSLALRTHCQT


MUTA_CAEEL/50-567                   SGWSLTEQDPYNNIIRTTIEAMASVFGGTQSLHTNSFDEAL--GLP---TKFSARIARNTQ
MUTA_HUMAN/61-576                   SGWSLTEQDPYNNIVRTAIEAMAAVFGGTQSLHTNSFDEAL--GLP---TVKSARIARNTQ
MUTA_MYCTU/24-525                   SLPMMTQRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIPGGFPGTAAGFARRIARNTQ
MUTA_PORGI/39-528                   SMWNKTVFDAHVNLLRTQTETMSAAIAGVDSITVLPFDVTY-----QQSDDFSERIARNQQ
MUTA_STRCM/29-530                   SPVMMTRRDPWVNMLRTTVACLGAGVGGADAVTVLPFDHEL--GLP--DA-FARRIARNTS
MUTB_MYCTU/50-578                   SGWSLTAQDVFNNVARTCIEAMAATQGHTQSLHTNALDEAL--ALP---TDFSARIARNTQ
MUTB_PORGI/33-549                   SGWSLTEQDPFNNVGRTCIEAMAAALGHTQSLHTNALDEAI--ALP---TDFSARIARNTQ
MUTB_PROFR/38-559                   SGWSLTAQDVYNNVVRTCIEAMAATQGHTQSLHTNSLDEAI--ALP---TDFSARIARNTQ
O28068_ARCFU/25-542                 AGCTLTAQQPENNIVRVALQALAAVLGGCQSLHTNSFDEAL--CLP---TEKAVRIALRTQ
O66005_STRCM/27-560                 AGVSLTAQQPYNNVVRTAVEALAAVLGGTNSLHTNALDETL--ALP---SEQAAEIALRTQ
SCPA_ECOLI/27-542                   SGWSLTEQDPYNNVIRTTIEALAATLGGTQSLHTNAFDEAL--GLP---TDFSARIARNTQ


MUTA_CAEEL/50-567                   IIIQEESGICNVADPWGGSYMMESLTDEIYEKALAVIKEIDELG----------------G
MUTA_HUMAN/61-576                   IIIQEESGIPKVADPWGGSYMMECLTNDVYDAALKLINEIEEMG----------------G
MUTA_MYCTU/24-525                   LLLLEESHVGRVLDPAGGSWFVEELTDRLARRAWQRFQAIEARG----------------G
MUTA_PORGI/39-528                   LLLKEECHFDKVIDPSAGSYYIETLTNSIGEEAWKLFLSVEDAG----------------G
MUTA_STRCM/29-530                   TILLEESHLARVIDPAGGSWYVERLTDELAHAAWDFFKEIERAD----------------G
MUTB_MYCTU/50-578                   LVLQQESGTTRPIDPWGGSYYVEWLTHRLARRARAHIAEVAEHG----------------G
MUTB_PORGI/33-549                   IYIQEETLVCKEIDPWGGSYYVESLTNELVHKAWTLIKEVQEMG----------------G
MUTB_PROFR/38-559                   LFLQQESGTTRVIDPWSGSAYVEELTWDLARKAWGHIQEVEKVG----------------G
O28068_ARCFU/25-542                 QIIAEESGVADVVDPLGGSYYIEWLTDRIEEEAMKYIEKIDEMG----------------G
O66005_STRCM/27-560                 QVLMEETGVANVADPLGGSWYIEQLTDRIEADAEKIFEQIRERGRRACPDGQHPIGPITSG
SCPA_ECOLI/27-542                   IIIQEESELCRTVDPLAGSYYIESLTDQIVKQARAIIQQIDEAG----------------G


MUTA_CAEEL/50-567                   MAKAVASGMTKLKIEEAAAKKQARIDAGKDVIVGVNKYRLDHEQQVE--VL--KIDNAKVR
MUTA_HUMAN/61-576                   MAKAVAEGIPKLRIEECAARRQARIDSGSEVIVGVNKYQLEKEDAVE--VL--AIDNTSVR
MUTA_MYCTU/24-525                   FVEAH-DFLAG-QIAECAARRADDIAHRRLAITGVNEYPNLGE----------PALPPGDP
MUTA_PORGI/39-528                   FTQAAETASIQKAVNASNIKRHQSVATRREIFLGTNQFPNFTEVAGDKITL-AQGEHDCNC
MUTA_STRCM/29-530                   QVAALRSGLVGDRIAATWAERRKKLARRREPITGVSEFPLLTERPVE--REPAPAAPPGG-
MUTB_MYCTU/50-578                   MAQAISDGIPKLRIEEAAARTQARIDSGQQPVVGVNKYQVPEDHEIE--VL--KVENSRVR
MUTB_PORGI/33-549                   MAKAIETGLPKLRIEEAAARTQARIDSHQQVIVGVNKYRLPKEDPID--IL--EIDNTAVR
MUTB_PROFR/38-559                   MAKAIEKGIPKMRIEEAAARTQARIDSGRQPLIGVNKYRLEHEPPLD--VL--KVDNSTVL
O28068_ARCFU/25-542                 MIKAIESGYVQREIQKSAYEKQKAIDEGEITVVGVNKYQIEEEIQIE--LL--RVDKAVVE
O66005_STRCM/27-560                 ILRGIEDGWFTGEIAESAFQYQRSLEKGDKRVVGVNCLEGSVTGDLE--IL--RVSHEVER
SCPA_ECOLI/27-542                   MAKAIEAGLPKRMIEEASAREQSLIDQGKRVIVGVNKYKLDHEDETD--VL--EIDNVMVR


MUTA_CAEEL/50-567                   EEQCAKLNHIRATRDAEKAQKALDAITEGAR------GNG---NLMELAIEAARARCTVGE
MUTA_HUMAN/61-576                   NRQIEKLKKIKSSRDQALAERCLAALTECAA-----SGDG---NILALAVDASRARCTVGE
MUTA_MYCTU/24-525                   TSPVRRYAAGFEALRDRSDH-HLARTGARPR-----------VLLLPLGPLAEHNIRTTFA
MUTA_PORGI/39-528                   VKSIEPLNFSRGASEFEALRLATEKSGKTPV-----------VFMLTIGNLAMRLARSQFS
MUTA_STRCM/29-530                   LPRVRRDEA-YEELRGRSDA-HLEATGARPK-----------VFIAALGPAAAHTARATFA
MUTB_MYCTU/50-578                   AEQLAKLQRLRAGRDEPAVRAALAELTRAAAEQGRAGADGLGNNLLALAIDAARAQATVGE
MUTB_PORGI/33-549                   KQQIERLNDLRSHRDEKAVQEALEAITKCV-ET--KEGN-----LLDLAVKAAGLRASLGE
MUTB_PROFR/38-559                   AEQKAKLVKLRAERDPEKVKAALDKITWAAGNPDDKDPDR---NLLKLCIDAGRAMATVGE
O28068_ARCFU/25-542                 -KQIRRLQEFRKNRDAKKVEEALDRLRKAAE-----KEDE---NLMPYVLDAVKARATLGE
O66005_STRCM/27-560                 -EQVRELAGRKGRRDDARVRASLDAMLAAAR------DGS---NMIAPMLEAVRAEATLGE
SCPA_ECOLI/27-542                   NEQIASLERIRATRDDAAVTAALNALTHAAQ------HNE---NLLAAAVNAARVRATLGE


MUTA_CAEEL/50-567                   ISDAMEKVFNRH
MUTA_HUMAN/61-576                   ITDALKKVFGEH
MUTA_MYCTU/24-525                   TNLLASGGIEAI
MUTA_PORGI/39-528                   SNFFGCAGYKLI
MUTA_STRCM/29-530                   ANLFMAGGVEPV
MUTB_MYCTU/50-578                   ISEALEKVYGRH
MUTB_PORGI/33-549                   ISDACEKVVGRY
MUTB_PROFR/38-559                   MSDALEKVFGRY
O28068_ARCFU/25-542                 MTDALRDVFGEF
O66005_STRCM/27-560                 ICGVLRDEWGVY
SCPA_ECOLI/27-542                   ISDALEVAFDRY